Brown, who is best known for his hit "Bustin' Loose" (interpolated on Nelly's 2002 single "Hot in Herre"), had apparently been ill for some time, and was hospitalized with pneumonia on April 18.
Brown's career began with an early stint as a guitarist for Jerry Butler and The Earls of Rhythm in the early '60's, before founding his own band, the Soul Searchers, launching D.C.'s go-go sound, a unique blend of percussive funk and soul and Latin music, which became a local phenomenon.
Brown inspired hundreds of local go-go bands, and influenced rappers like Wale, Tabi Bonney and many more. Hip-hop historian Jeff Chang is quoted as saying "Everywhere else, Hip Hop rules. But the sound of D.C. is Go Go, for one reason. His name is Chuck Brown."
Brown's song "L.O.V.E." was recently nominated for a Grammy for best R&B performance by a duo or group in 2011. He leaves behind two sons, Wiley and Nekos Brown, both of whom played football for Virginia Tech.