Keys announced Tuesday that her organization, Keep a Child Alive, will honor Winfrey at its Black Ball event on Nov. 1.
Key says in a statement that the media mogul is "a personal inspiration to me because her philanthropic work truly comes from the heart."
Winfrey's humanitarian efforts include building schools in South Africa.
Keep a Child Alive was founded in 2003. It assists those affected by HIV/AIDS in Africa and India. Keys says this year's Black Ball will pay "special tribute to the empowerment of women - the heartbeat, soul, and backbone of the AIDS movement."
The ninth annual event will take place at New York's Hammerstein Ballroom. Past honorees include former President Bill Clinton, Sir Richard Branson and Bono.
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